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There are 14.5 million women-owned businesses in the United States. Firms run by female executives employ 12.9 million workers and generate $3.3 trillion annually.
You may be surprised to learn several Fortune 500 companies are run by women. No longer are female business leaders an anomaly. Although there are still more male-owned businesses, women entrepreneurs are catching up, owning more than 39 percent of businesses in the United States, according to the Wells Fargo Impact of Women-Owned Businesses report.
Read the stories of the successful businesswomen below, and maybe you’ll find enough inspiration to become an entrepreneur yourself. [Read related article: How to Be an Inspirational Leader]
Here are the stories of women who became the heads of well-known and Fortune 500 companies.
Phebe Novakovic is the chairman and chief executive officer of this Fortune 500 company, which has business in aerospace, combat systems, information systems and technology, and marine systems. Novakovic brings unique expertise to the company, having been a former intelligence officer. She has been ranked among the most powerful women by both Fortune and Forbes.
Not only was Ursula Burns the chairman and CEO of Xerox from 2009 to 2016 and chairman from 2010 to 2017, she was the first African-American woman to head a Fortune 500 company. She stepped down when the company split. Since then, she has served as a board member for several companies, including Uber, and is currently the chairwoman of Teneo, a management consulting company. Xerox is more than office copy equipment; they offer document management and workplace optimization services as well as production equipment and software. [Read related article: The Best Document Management Software of 2025]

Mary Dillon took over as president and CEO of Foot Locker, Inc. in September 2022. She was responsible for overseeing all business operations and development for the chain of approximately 2,400 retail sporting goods stores until September 2025 when Dick’s Sporting Goods acquired Foot Locker and its brands Kids Foot Locker, Champs Sports, atmos and WSS stores. Dillon formerly held leadership roles at Ulta, McDonald’s and PepsiCo.
At 33 years of age, Lynsi Snyder became one of the youngest American billionaires as well as the president and owner of the popular burger chain founded by her grandparents in 1948. Snyder more than doubled the number of In-N-Out Burger locations, expanding to Idaho, Texas, Oregon and Colorado. In-N-Out Burger is a privately owned company and Snyder vows she will never sell it.
>> Read More: An interview with Lynsi Snyder in business.com’s newsletter.

Former CEO Susan Wojcicki, who passed away in August 2024, ran YouTube until February 2023. She also worked for Google and its parent company, Alphabet, becoming the 16th-ever Google employee and working on AdSense, Google Analytics, Google Books and Google Images. In 2006, she advocated buying YouTube and subsequently went on to run it, growing its revenue significantly during her tenure.
>> Learn More: Why Every Brand Should Have a YouTube Channel
Jane Hamilton Nielsen was the chief operating officer and chief financial officer of fashion clothing and lifestyle brand Ralph Lauren Corp., overseeing its global finance, business development and real estate organizations from 2016 to 2024. She was also responsible for investor relations, procurement, IT and global logistics. Nielsen also worked as the chief financial officer of Coach, Inc. and the chief financial officer and senior vice president of Pepsico Beverages & Foods. She is a board member of Mondelēz International.
In January 2023, Maria Black became the president and CEO of ADP, the market leader in outsourced human resource functions, such as payroll, benefit administration and tax services. At the helm of this Fortune 500 company operating in more than 140 countries, Black endorses using data-driven insights to drive social good, creating a more diverse, equitable and inclusive workplace for ADP’s clients.
Karla R. Lewis ascended to the helm of a Fortune 500 company in January 2023, becoming the CEO of Reliance, a diversified metals solutions provider. Lewis has been a member of Reliance’s executive team for more than 30 years, previously serving as the company’s corporate controller, chief financial officer, senior vice president and executive vice president.
In 1978, Janice Bryant Howroyd founded ActOne Group, a personnel, employment and workforce management company that currently operates in 19 countries and has thousands of clients worldwide. Howroyd is the first African American woman to build a billion-dollar company.
Co-founded by Stanford-trained dermatologists Katie Rodan and Kathy Fields, Rodan + Fields made it big with their flagship acne product, Proactiv, in 1995. After that early success, they started another skincare company; Rodan + Fields was a multilevel marketing company selling directly to consumers. However, in 2024, the company transitioned from the multi-level direct selling model to a more traditional affiliate marketing channel to streamline operations.
The following is a list of resources for women who are starting businesses or who are trying to take their businesses to the next level.
Kimberlee Leonard contributed to the reporting and writing in this article.